Australian researchers have identified a surprising mechanism focusing on telomeres -- protective caps at the ends of chromosomes -- that can help cells defend against cancer. Telomeres are known to play a key role in ageing and cancer prevention. However, with age, these structures naturally shorten, signaling ageing cells to stop dividing -- a crucial safeguard against cancer, according to the study by Sydney-based Children's Medical Research Institute (CMRI) on Monday, Xinhua news agency reported. "Our data shows telomeres are much more active. They can acutely respond to stress and actively open up to turn on a cellular response that looks like ageing. They do this to avoid cancer," said Tony Cesare of the Genome Integrity Unit at CMRI. Cesare and his team worked with their collaborators at the University of Kyoto to understand the "active" role that telomeres can play in avoiding cancer. The study, published in the journal Nature Communications, revealed that telomeres do more than just passively shorten with age. They actively respond to stress by triggering cellular ageing processes to prevent cancer from developing. "Most people think of telomeres as a passive entity that shortens with cell division. This is a passive fail-safe used during ageing," Cesare said. By inducing cell cycle arrest or programmed cell death, telomeres help eliminate cells with chromosomal damage before they can divide uncontrollably, he said, adding this discovery introduces a previously unknown anti-cancer function of telomeres. Beyond its significance for telomere biology, Cesare suggests that this breakthrough could open new avenues for cancer treatment -- targeting telomeres to trigger cell death in cancerous cells may offer a promising therapeutic strategy. As per the latest estimates, in 2022, there were an estimated 20 million new cancer cases and 9.7 million deaths. About 1 in 5 people develop cancer in their lifetime, approximately 1 in 9 men and 1 in 12 women die from the disease, according to data from the World Health Organization. Also Read: Cancer incidence steadily rising in India; lifestyle changes essential: Doctors This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
17 March,2025 02:08 PM IST | Mumbai | IANSThe '13th Gut Microbiota for Health World Summit' in Washington, DC, over the weekend revealed how cutting-edge research on gut microbiome science is being applied to clinical practice. The summit showcased the latest microbiome research on coronavirus, plant and dairy-based protein, as well as probiotics. A novel study found that the gut microbiome in children is altered post-COVID-19 infection, much like it is in adults. Researchers found a significant decrease in beneficial bacteria, like Lacticaseibacillus and Bifidobacterium, in children who had COVID-19 compared to those who didn’t. These bacteria help reduce inflammation and support gut health. Children with lingering symptoms also showed different types of bacteria, in addition to elevated markers of inflammation and decreased barrier function in the gut. Future research will examine immune responses and potential microbiome-targeted therapies for persistent post-COVID-19 symptoms. In another study, researchers analysed 35 plant-based and 23 dairy-based foods and found that nearly 50% of tested plants and milk and dairy products contain S100B, a helpful protein that binds calcium. The study suggested that S100B may interact with gut bacteria to promote a healthy microbiome, potentially influencing inflammatory bowel disease (IBD). The findings open the door for future dietary applications, such as using S100B in supplements and nutraceuticals. A meta-analysis of 10 studies, including 2,345 patients, showed that probiotics significantly reduced abdominal pain, bloating, and vomiting after a colonoscopy. While there was no significant reduction in nausea, constipation, gas, or diarrhoea, these findings suggest probiotics could improve patient recovery and encourage more individuals to undergo the crucial procedure. The event – organised by the American Gastroenterological Association (AGA) and the European Society of Neurogastroenterology and Motility (ESNM) – brought together clinicians, researchers, nutritionists, and dieticians from around the world.
17 March,2025 10:45 AM IST | New York | IANSA recent study has made significant progress in uncovering the microscopic mechanism behind heavy-ion cancer therapy, which is expected to optimise cancer treatment strategies and promote the development of new radiotherapy technologies. The findings, led by researchers from the Institute of Modern Physics (IMP) of the Chinese Academy of Sciences and their collaborators, were recently published as a highlighted paper in the journal Physical Review X, Xinhua news agency reported. Heavy-ion therapy, a cutting-edge radiotherapy technique, uses heavy-ion beams to destroy cancer cells. Since the concept was proposed in 1946, over 50,000 patients worldwide have undergone heavy-ion treatment. "Under the same radiation dose, heavy ions exhibit two to three times greater cancer-cell-killing efficiency than traditional X-ray radiotherapy," said Xu Shenyue, a researcher with the IMP. Heavy ions can more efficiently cause DNA double-strand breaks in tumour cells, resulting in stronger biological effects. But the specific microscopic mechanism underlying these effects had long been unclear, Shenyue added. Researchers conducted experiments at the heavy-ion research facilities in Lanzhou, northwest China's Gansu Province, to address this question. For the first time, they observed an intermolecular energy and proton transfer cascade mechanism triggered by heavy-ion irradiation in biomolecular clusters. "The observed mechanism sheds light on the molecular mechanisms of radiation damage, and may play an essential role in optimising radiotherapy techniques in the future," said Ma Xinwen, another researcher with the IMP. The study was conducted by scientists from the IMP, in collaboration with researchers from Russia's Irkutsk State University, Germany's Heidelberg University, the University of Science and Technology of China, Xi'an Jiaotong University and Lanzhou University. Meanwhile, a recent report said that the scientists are working on a new type of antibody that could help fight treatment-resistant breast and ovarian cancers. The antibody, known as IgE, has shown the ability to stimulate the immune system and slow down tumour growth. Currently, IgG antibodies are commonly used in immunotherapy to activate the body’s immune system against cancer. This treatment is often preferred over chemotherapy and radiation because it specifically targets cancer cells.
17 March,2025 10:24 AM IST | New Delhi | IANSA team of researchers has revealed powerful virtual reality (VR) treatment for speech anxiety, that is becoming increasingly more common over time globally. Published in the journal Frontiers, the study reported work by Dr Chris Macdonald from University of Cambridge in the UK who created an online platform where users transform into skilled and confident public speakers. On the platform, tailored course material develops key skills and life-like virtual reality training environments build confidence. “In physical reality, a user might be practising a presentation alone in their bedroom but on the new virtual reality platform, they can experience the sensation of presenting to a wide range of increasingly challenging photorealistic audiences,” said Dr Macdonald. By developing a method that converts smartphones into VR headsets, Dr Macdonald has made sure that the platform is accessible to all. The platform has been clinically proven to significantly increase levels of confidence for most users after a single 30-minute session. In the most recent trial with students from Cambridge and University College London (UCL), it was found that a week of self-guided use was beneficial to 100 per cent of participants. The platform helped all users in one or more of the following ways: to feel more prepared, more adaptable, more resilient, more confident, to be better able to manage nerves, and to feel less anxious. A user-centric iterative process ensured that the platform would work ‘in the wild’. In between each rebuild thus far, the platform has hosted over 50,000 practice presentations from remote beta users. To further stress test the software and hardware, in-person events were organised, one of which involved over 1,000 members of the public using the platform in suboptimal conditions in a demo room in Cambridge. To further expand and deepen the participant pool, the lab went on tour. This included stops at the largest science and technology events such as New Scientist Live as well as less formal settings such as a local market, library, community centre, church, and even someone’s living room. Speech anxiety and the fear of public speaking impact most people, and it is becoming increasingly more common over time. The platform has immense potential to empower individuals to overcome their fear of public speaking, ultimately enhancing not only their quality of life but also their capacity to become a driving force of positive change in the world,” said the authors.
17 March,2025 10:09 AM IST | New Delhi | IANSScientists at Osaka University in Japan have devised a new AI model to estimate a person’s biological age — a measure of how well their body has aged, rather than just counting the years since birth. Using just five drops of blood, this new method analyses 22 key steroids and their interactions to provide a more precise health assessment. The team’s breakthrough study, published in Science Advances, offers a potential step forward in personalised health management, allowing for earlier detection of age-related health risks and tailored interventions. “Our bodies rely on hormones to maintain homeostasis, so we thought, why not use these as key indicators of aging?” said Dr Qiuyi Wang, co-first author of the study. To test this idea, the research team focused on steroid hormones, which play a crucial role in metabolism, immune function, and stress response. The team developed a deep neural network (DNN) model that incorporates steroid metabolism pathways, making it the first AI model to explicitly account for the interactions between different steroid molecules. One of the study’s most striking findings involves cortisol, a steroid hormone commonly associated with stress. The researchers found that when cortisol levels doubled, biological age increased by approximately 1.5 times. This suggests that chronic stress could accelerate aging at a biochemical level, reinforcing the importance of stress management in maintaining long-term health. “Stress is often discussed in general terms, but our findings provide concrete evidence that it has a measurable impact on biological aging,” said Professor Toshifumi Takao, a corresponding author and an expert in analytical chemistry and mass spectrometry. The researchers believe this AI-powered biological age model could pave the way for more personalised health monitoring. Future applications may include early disease detection, customised wellness programmes, and even lifestyle recommendations tailored to slow down aging. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
17 March,2025 10:03 AM IST | New Delhi | IANSThe new study conducted among urban Indian corporate employees, has found that vitamin B12 deficiency, crucial for neurological function and energy metabolism, was significantly higher among men, with 57.16 per cent showing insufficient or deficient levels. Meanwhile, 49.9 per cent of women also exhibited deficiencies, emphasising the importance of dietary adjustments and supplementation for overall well-being. The study was released earlier this week by Indian digital healthcare company MediBuddy highlighting nutrient deficiencies among Indian corporate professionals aged 40–50. It analysed data from around 4,400 individuals (3,338 men and 1,059 women) in the age group, brings to the fore the urgent need for targeted health interventions and preventive care strategies, particularly for men who exhibit a higher prevalence of key deficiency. Contrary to the common belief that urban men have an adequate diet, the study suggests that poor gut absorption, dietary choices, and a predominantly vegetarian diet could be contributing factors to this widespread deficiency. Several underlying reasons may explain this trend:1. Poor absorption: Even in individuals consuming B12-rich foods, malabsorption issues such as suboptimal stomach acid production (common with age), gastrointestinal disorders, or long-term use of medications like antacids and metformin can hinder effective B12 absorption. Another big issue is gut microbiome imbalance causing poor absorption.2. Dietary choices: Corporate professionals, particularly vegetarians or vegans, are at a higher risk of deficiency since natural sources of B12 are primarily found in animal-based foods (meat, fish, dairy, and eggs). Even those consuming dairy and eggs may still struggle to meet their daily requirements without fortified foods or supplementation.3. Sedentary lifestyles and metabolic stress: High-pressure corporate jobs often lead to erratic eating habits, increased alcohol consumption, nicotine use and stress, which can further deplete B12 levels. Dr Gowri Kulkarni, head of medical operations, MediBuddy, speaking about the findings, said, “Preventive care is the cornerstone of long-term health, and these findings reinforce the need for early intervention, especially for employees in high-pressure corporate environments. At MediBuddy, we are committed to empowering individuals with accessible healthcare solutions that encourage proactive wellness. Through timely screenings, digital health tracking, and expert-led guidance, we aim to shift healthcare from a reactive to a preventive approach, ensuring better long-term health outcomes.” As India's corporate sector continues to expand, these findings underline the importance of personalised health assessments that go beyond standard metrics. Regular health screenings focused on nutritional status and metabolic markers can help identify issues before they progress to more serious conditions, particularly for men, who are often less likely to seek preventive care.
16 March,2025 10:01 PM IST | Mumbai | mid-day online correspondentTrying to lose weight? A new study claims replacing animal products with plant-based foods like soy milk and vegan meat that are ultra-processed, can lead to significant weight loss. The research by the Physicians Committee for Responsible Medicine looked at the role of plant-based processed foods in weight loss. High-processed foods -- rich in sugar, salt, and fat -- are known to be unhealthy and contribute to weight gain, obesity, and a host of diseases. “Our research shows that choosing a bagel instead of bacon for breakfast or a veggie burger instead of a hamburger for dinner is the best option if you are looking to lose weight,” said Hana Kahleova, director of clinical research for the Physicians Committee for Responsible Medicine. “Filling your plate with plant-based foods -- even if they are considered ultra-processed like soy milk and vegan meat and yogurt alternatives -- instead of animal products can have a positive impact on your weight and overall health,” Kahleova added. The findings, published in the journal Nutrition & Metabolism, showed that participants in the vegan group decreased consumption of animal products and increased plant-based foods. This led to an average weight loss of 5.9 kilograms, compared to an insignificant change in the control group. The top three predictors of weight loss were reduced consumption of processed animal foods (such as smoked fish), unprocessed or minimally processed animal foods (such as milk, beef, and eggs), and ultra-processed animal foods (such as cheese, fried chicken, and sausage). This appears to have resulted from reduced calorie and fat intake and increased fiber intake, as well as calorie burn from increased after-meal metabolism, said the researchers. “Our new study is an important reminder that plant-based foods that are considered processed, like canned beans, cereal, and veggie burgers, are actually part of a healthy diet that can help fight diet-related chronic disease epidemics,” Kahleova said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
16 March,2025 10:17 AM IST | New Delhi | IANSA team of US researchers have developed an artificial intelligence (AI) based system that may help assess cognitive impairments and curb the risk of developing Alzheimer’s disease or dementia in older adults. Mild cognitive impairment (MCI) can be an early indicator of Alzheimer’s disease or dementia, so identifying people with cognitive issues early could lead to interventions and better outcomes. However, diagnosing MCI can be a long and difficult process, especially in rural areas where access to licensed neuropsychologists is limited. Researchers from the University of Missouri created a portable system that comes with a depth camera, a force plate, and an interface board. The study showed it can efficiently measure multiple aspects of motor function. The team examined older adults, some of whom had MCI, and asked them to complete three activities: standing still, walking, and standing up from a bench. Participants had to complete these activities while counting backward in intervals of seven at the same time. Based on their performance, which was captured by the new portable system, the data was fed into a machine learning model -- a type of artificial intelligence -- that accurately identified 83 per cent of those in the study with MCI. “The areas of the brain involved in cognitive impairment overlap with areas of the brain involved in motor function, so when one is diminished, the other is impacted as well,” said Trent Guess, an associate professor in the College of Health Sciences, at the varsity. “These can be very subtle differences in motor function related to balance and walking that our new device is able to detect but would go unnoticed through observation,” Guess added. With the number of people globally with Alzheimer’s disease expected to surge, the portable device has the potential to help millions of older adults given that MCI is one of the precursors to Alzheimer’s and dementia. “This portable system has many other applications, too, including looking at those with concussions, sports rehabilitation, ALS and Parkinson’s disease, knee replacements and hip replacements,” Guess said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
16 March,2025 10:06 AM IST | New Delhi | IANSA team of US researchers has identified high-risk cells in fallopian tubes that may trigger a deadly form of ovarian cancer. The discovery of the high-risk cells -- a subset of progenitor cells that reside in fallopian tube supportive tissue, or stroma -- may pave the way for better approaches to prevent and detect high-grade serous ovarian cancer (HGSOC), said the team from the University of Pittsburgh. HGSOC is a type of ovarian cancer that starts in the fallopian tubes and spreads to the ovaries. It is the most common form of ovarian cancer. "Ovarian cancer is a leading cause of death from gynecologic cancer, but we currently have no way to detect it early and no prevention strategies apart from surgical castration, which is only indicated in high-risk women," said Lan Coffman, Associate Professor of malignant hematology and medical oncology in the Pitt School of Medicine. "Understanding the underlying biology of how ovarian cancer forms is critical to improving outcomes for our patients," Coffman said, in the paper, published in the journal Cancer Discovery. HGSOC begins in the fallopian tubes when healthy epithelial cells transform into precursor lesions known as serous tubal intraepithelial carcinoma (STIC). These STIC lesions often develop into HGSOC tumours. To find out, Coffman and her team turned to the stroma -- the non-cancerous connective tissue that helps cancer grow. In the stroma of ovarian cancer, a type of progenitor cell normally involved in the growth and repair of healthy tissue (mesenchymal stem cells (MSCs) becomes reprogrammed by tumour cells to support cancer growth. Further probe revealed that cells that looked like cancer-associated MSCs in the fallopian tubes of healthy women, had higher risk of ovarian cancer. The risks include older age or with mutations in the BRCA gene -- suggesting that they play a role in cancer initiation. When the researchers introduced these high-risk MSCs into organoids, or mini-organs, derived from patient fallopian tube tissue, healthy epithelial cells transformed into cancerous cells. "High-risk MSCs promote DNA damage in epithelial cells and then help those mutated cells survive," explained Coffman. "It's the perfect storm for cancer initiation." This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
16 March,2025 09:59 AM IST | New Delhi | IANSBones form an integral support system for the body, providing structure, protecting essential organs and facilitating movement. With an increase in age generally comes a decrease in bone density. Hence, it becomes important to prioritise and protect your bone health, especially after the age of 30. There are two basic pillars for ensuring bone health – nutrition and exercise. Nutrition for maintaining bone health after 30 It is important to focus on nutrition when it comes to maintaining bone health. One has to have a balanced diet, which contains ample proteins. Calcium is an important nutrient that strengthens bones. “Calcium is generally found in dairy products and non-vegetarian food. However, vegetarians and vegans can opt for calcium supplement if required, as per doctor’s advice,” says Dr Sachin Bhonsle, Senior Consultant - Orthopedics & Joint Replacement Surgeries, Fortis Hospital, Mulund. Another nutrient that is essential to maintain bone health is Vitamin D. “Calcium needs a transport system for absorption. Vitamin D plays this role. It is not readily available in foods, except some amount in eggs and other non-vegetarian food. One can get daily dose of Vitamin D from sunlight,” explains Dr Bhonsle. Exercise for maintaining bone health after 30 The second important pillar for strong bones is daily exercise. One can opt for weight-bearing exercises for the lower body like running, jogging, racquet sports, gymming, cycling, etc. Dr Bhonsle mentions that weight training exercises are helpful for the upper body. Other lifestyle habits for maintaining bone health after 30 Apart from nutrition and exercise, certain lifestyle habits can also help strengthen bone health, while others can lead to its deterioration. For example, habits like consumption of tobacco and alcohol are responsible for harming bone health. While genetic factors play a role in bone health, diet, exercise and other lifestyle habits are controllable factors that can help maintain bone density and prevent bone-related issues as one ages. Disclaimer: This is for informational purposes only and does not replace professional medical advice. Kindly consult a qualified medical expert for personalised guidance.
15 March,2025 02:15 PM IST | Mumbai | mid-day online correspondentThe quality of diet and waist-to-hip ratio in midlife are associated with brain connectivity and cognitive performance in later life, according to a study. Researchers from Oxford University and University College London in the UK found that people in midlife engaging in healthy eating had an increased hippocampal functional connectivity to the occipital lobe and cerebellum; as well as a better white matter. These improved working memory, executive function, and overall cognitive performance in middle-aged adults. On the other hand, those with higher waist-to-hip ratio in midlife had a widespread decrease in white matter integrity, leading to implications in memory and executive function. Reduced fractional anisotropy in these regions was linked to poorer cognitive performance. “Healthier diets and lower waist-to-hip ratio during midlife correlate with improved brain health in older age,” said the researchers in the study, published in JAMA Network Open. Global shifts in dietary habits have contributed to rising rates of obesity, cardiovascular disease, and diabetes, all of which are linked to an increased risk of dementia. Research into the relationship between diet, metabolic health, and brain function has primarily focused on individual nutrients, with fewer studies assessing overall diet quality and body fat distribution over extended periods. Previous studies have suggested that midlife is a critical window for cognitive health interventions, yet long-term study evidence on diet and brain connectivity remains limited. The study analysed longitudinal changes in diet quality and waist-to-hip ratio to assess their association with hippocampal connectivity and cognitive function in ageing. The team included 512 participants in the diet quality analysis and 664 in the waist-to-hip ratio analysis. The findings suggest that interventions to improve diet and manage central obesity might be most effective between ages 48 and 70 years. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
15 March,2025 09:54 AM IST | Mumbai | IANSADVERTISEMENT
