To develop the new AI model, the researchers used routinely gathered, non-invasive and low-cost patient data - cognitive tests and structural MRI scans revealing grey matter shrinkage - from over 400 participants in a research cohort in the US
Image for representational purposes only. Photo Courtesy: iStock
Scientists at the Cambridge University in the UK have developed an artificial intelligence (AI)-based tool that can help detect patients with early dementia whether they will remain stable or develop Alzheimer's.
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Dementia is a global healthcare challenge, affecting over 55 million people at an estimated annual cost of $820 billion.
The cases are expected to almost triple over the next 50 years.
To develop the new AI model, the researchers used routinely gathered, non-invasive and low-cost patient data - cognitive tests and structural MRI scans revealing grey matter shrinkage - from over 400 participants in a research cohort in the US.
They next evaluated the model with real-world patient data from an additional 600 participants in the US cohort, as well as longitudinal data from 900 persons in memory clinics in the United Kingdom and Singapore.
The algorithm was able to identify between persons with stable mild cognitive impairment and those who developed Alzheimer's disease within three years, according to the story published in the journal EClinicalMedicine.
It successfully identified those who developed Alzheimer's in 82 per cent of cases and those who did not in 81 per cent of cases using only cognitive tests and an MRI scan which provides hope that this model may well be accurate.
Professor Zoe Kourtzi from the Department of Psychology at the University of Cambridge said this tool would be good at predicting whether or not someone will progress to Alzheimer’s, and that since it has been tested in real life too, generalisations can be made.
Ben Underwood from the University of Cambridge said this would help alleviate many existing concerns for the patients and their families.
Earlier, we also published:
Obesity, smoking key triggers for Alzheimer's Disease, say experts
Obesity and smoking are key triggers for Alzheimer's Disease, said health experts on Monday, stressing the need to control both, especially in young adults.
The experts explained that obesity and smoking are the major risk factors for vascular dementia and can trigger Alzheimer's owing to the inflammation caused due to smoking.
“Smoking damages blood vessels, reducing blood flow to the brain, which can harm brain cells. Obesity is linked to inflammation and insulin resistance, both detrimental to brain health,” Dr. Vikas Mittal, pulmonologist at the CK Birla Hospital, Delhi, said.
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Curbing the major risk factors are important as a recent study published in the journal The Lancet showed that global dementia cases are set to triple, with 153 million living with dementia by 2050.
Alzheimer's, the most common cause of dementia, accounting for 60 to 80 per cent of cases, is also expected to soar.
“Obesity also causes conditions like diabetes and cardiac disease which are known risk factors for Alzheimer’s. The presence of these conditions worsens brain health while promoting inflammation, oxidative stress, and vascular damage, which leads to memory decline and increase in Alzheimer’s Disease,” Dr. Anurag Saxena, HOD and Cluster Head Neurosurgery, Manipal Hospital Dwarka, said.
Additionally, obesity impairs metabolic functions and insulin signalling which increases the risk of neurodegeneration.
On the other hand, “smoking worsens oxidative stress and inflammation in the brain which increases the development of Alzheimer’s.
“The harmful chemicals in cigarettes like nicotine and tar damage blood vessels and interfere with blood flow. Smoking can not only accelerate Alzheimer’s Disease but also other forms of dementia,” Dr. Anurag said.
Moreover, people with a family history of Alzheimer’s are more prone to the condition if they smoke.
The combination and genetic factors and the effects of smoking increases the progress of Alzheimer’s symptoms, the doctor noted.
Dr. Shailesh Rohatgi, HOD, Department of Neurology, DPU Super Speciality Hospital at Pune, said that he advised maintaining a balanced lifestyle and eating habits and keeping a constant check, as vascular dementia can even develop at an early age due to various lifestyle habits.
He also stressed on “daily activities which are not just limited to physical movement but also engaging the brain. It is important to engage your brain in mental activities like board games.”
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