A team of researchers from the US-based University of North Carolina has identified a potential treatment for a rare genetic disorder -- 'Angelman syndrome', a new study said on Monday. Angelman syndrome is caused by mutations in the maternally inherited UBE3A gene and is characterised by poor muscle control, limited speech, epilepsy, and intellectual disabilities, explained researchers in the study published in the journal Nature Communications. Ben Philpot, PhD, the Kenan Distinguished Professor at the UNC School of Medicine, and his lab have identified a small molecule that could be safe, non-invasively delivered, and capable of 'turning on' the dormant paternally-inherited UBE3A gene copy brain-wide, which would lead to proper protein and cell function, amounting to a kind of gene therapy for individuals with Angelman syndrome. "This compound we identified has shown to have excellent uptake in the developing brains of animal models," said Philpot, who is a leading expert on Angelman syndrome. As per researchers, UBE3A helps regulate the levels of important proteins; missing a working copy leads to severe disruptions in brain development. The researchers screened over 2,800 small molecules to determine if one could potently turn on paternal UBE3A in mouse models with Angelman syndrome. They found that a compound -- (S)-PHA533533, which was previously developed as an anti-tumour agent, caused neurons to express a fluorescent glow that rivalled that induced by topotecan, meaning that its effect was potent enough to successfully turn on paternal UBE3A. Researchers were able to confirm the same results using induced pluripotent stem cells derived from humans with Angelman syndrome, indicating that this compound has clinical potential, the study mentioned. In addition, they observed that (S)-PHA533533 has excellent bioavailability in the developing brain, meaning it travels to its target with ease and sticks around. "We were able to show that (S)-PHA533533 had better uptake and that the same small molecule could be translated in human-derived neural cells, which is a huge finding," said Hanna Vihma, PhD, and first author of the study. Also Read: Zika virus can lead to neurological complications: Doctors This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
08 July,2024 04:30 PM IST | San Francisco | IANS
As cases continue to climb in Karnataka and Maharashtra, Mumbai doctors caution about the neurological risks associated with the Zika virus. Last week, a 74-year-old man succumbed to this infection in the Shivamogga district of Karnataka. According to the Karnataka Health Ministry, he was discharged from the hospital on Thursday and was receiving treatment at home. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; While his diagnosis could only report fever, body aches and rashes, the Zika virus infection has been linked with Guillain-Barré Syndrome (GBS), a rare autoimmune disorder that takes a toll on the nervous system, informs Dr Manjusha Agarwal, a senior consultant working with Gleneagles Hospitals in Mumbai. Research is yet to confirm this, she adds. With the virus turning fatal, Midday sought insights from Mumbai health experts who shed light on the virus's potential neurological impacts, the role of genome sequencing in understanding the virus and progress in vaccine development. Link between Zika virus and neurological conditionsTracing the connection between the Zika virus and neurology, Dr Divya Gopal, internal medicine at Sir HN Reliance Hospital tells Midday how the virus may give rise to microcephaly amongst infants. “When acquired, this condition leads to babies born with abnormally small heads due to incomplete brain development. Zika infection during pregnancy gives rise to serious neurological abnormalities in infants, collectively termed congenital Zika syndrome (CZS).” This connection has led researchers to examine how the virus penetrates the placenta and infects the fetus, causing adverse impacts on brain development. In line with these observations, a study published in "The New England Journal of Medicine" links the virus with neurological complications. Conducted during the 2015-2016 outbreak in Brazil, the paper found an association between Zika virus infection during pregnancy and the occurrence of microcephaly in newborns. Besides microcephaly, CZS may include seizures, developmental delays as well as vision and hearing impairments. Furthermore, Agarwal informs that Guillain-Barré Syndrome (GBS) caused by the virus, can result in muscle weakness and in severe cases, paralysis. The connection between the virus and GBS was observed during outbreaks, where an increase in GBS cases started coinciding with Zika virus infections. Role of genome sequencingThe virus spreading in India has been found to belong to the family Flaviviridae and the genus Flavivirus, shares Gopal. Zika virus is primarily transmitted by the Aedes mosquito which is also responsible for the spread of dengue, Chikungunya and yellow fever viruses. In most areas, the primary vector of these viruses is Aedes aegypti, with Aedes albopictus a proven or potential vector in some settings. In this scenario, genome sequencing becomes crucial as it helps in identifying and comparing the genetic variations within different strains of the virus. This also helps in understanding the evolution of the virus over time across different geographies, informs Dr P. Praneetha, consultant, department of general medicine, Meenakshi Mission Hospital, Mumbai. Agarwal adds that genome sequencing helps virologists decode the virus's genetic makeup and detect specific mutations that may impact its transmission patterns. This information is essential for developing vaccines to tackle the spread of Zika. Also, it helps to predict future outbreaks and guides when it comes to public health strategies for effective prevention and control measures against Zika. Is there a cure for the Zike virus?Gopal hints at ongoing efforts towards developing vaccines and medicines for the Zika virus. “Vaccine development has made strides, with some candidates showing promising results in preclinical and early-stage clinical trials. Yet, despite progress, challenges remain in achieving a definitive cure.” Effective vaccines could provide a long-term solution to prevent Zika infections, however, they remain in the developing stage by scientists. Potential drugs are also been identified for treatment, informs Agarwal. Innovative approaches such as gene editing techniques, to create targeted therapies that can combat Zika more effectively are also taken into consideration. How does the virus transmit between hosts?Zika virus spreads primarily through mosquito bites and from pregnant women to their fetuses. Additionally, sexual transmission has been identified as another route of spread. The Aedes aegypti and Aedes albopictus mosquitoes are the main vectors responsible for transmitting the virus to humans when they feed on blood, shares Agarwal. Moreover, the mosquito bites mostly during the daytime. This virus spreads via sexual contact and can be present in semen for several weeks after infection, posing a risk of spreading through unprotected intercourse. It is the need of the hour to understand the diverse transmission patterns and take necessary precautions. Watch out for these symptoms The initial symptoms of the Zika virus are generally mild and can include: 1. Fever2. Rash3. Joint Pain4. Conjunctivitis (red eyes)5. Headache Praneetha outlines that symptoms typically appear 3 to 14 days after being bitten by an infected mosquito and usually last for several days to a week. Many people infected with Zika virus do not experience symptoms or have only mild symptoms. In some cases, fever with a rash can be the first symptom. Others may experience headache, joint pain and redness in the eyes. Very rarely, the Zika virus can affect the brain and nerves in adults, potentially causing paralysis and difficulty in walking. Diagnosing Zika virusThere are several steps to ascertain whether the virus is present or not. The patient’s symptoms, travel history (if applicable), and potential exposure to mosquitoes or infected individuals are first evaluated. If the symptoms are present then a Lab test is advised which includes” 1. Polymerase Chain Reaction (PCR), is used to detect the RNA of the Zika virus in blood, urine or other body fluids.2. Praneetha stresses that in detecting recent or past Zika virus infections. “Serological tests are also recommended which basically to detect Zika virus-specific antibodies produced by the immune system in response to infection.” Post diagnosis, the mainstays of Zika treatment are rest, fluid maintenance and symptom management, concludes Gopal. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} };
08 July,2024 01:07 PM IST | Mumbai | Ainie RizviZoonoses are infectious diseases that can transfer between animals and humans, such as rabies, anthrax, influenza (H1N1 and H5N1), Nipah, Covid-19, brucellosis, and tuberculosis; however, not all diseases are 'zoonotic', said the Department of Animal Husbandry and Dairying (DAHD) on Sunday. The department has organised an interactive session chaired by Alka Upadhyaya, the Secretary of Animal Husbandry and Dairying (AHD), to observe World Zoonoses Day. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; According to the Animal Husbandry Department, understanding which diseases are zoonotic is crucial for effective public health strategies and preventing unnecessary fear and stigmatisation of animals. "Raising awareness aids in early detection, prevention, and control, ultimately protecting public health. Educating the public about the distinction between zoonotic and non-zoonotic diseases helps reduce unwarranted fear and promotes a more informed approach to animal health and safety," said DAHD. To mitigate the risk of zoonotic diseases, DAHD has launched a nationwide campaign for Brucella vaccination of bovine calves under the National Animal Disease Control Programme and undertaken rabies vaccination under Assistance to States for Control of Animal Diseases. The department said that it is also implementing a comprehensive nationwide surveillance plan for economically important animal diseases. Additionally, under the One Health approach, the National Joint Outbreak Response Team has been established, comprising experts from the Ministry of Health and Family Welfare, ICMR, DAHD, ICAR, and the Ministry of Environment, Forest and Climate Change. India has the largest livestock population, with 536 million livestock and 851 million poultry, which accounts for nearly 11 per cent and 18 per cent of the global livestock and poultry population, respectively. India is the world's largest producer of milk and the second-largest producer of eggs. World Zoonoses Day is celebrated in honour of Louis Pasteur, who administered the first successful rabies vaccine, a zoonotic disease, on July 6, 1885.
08 July,2024 01:07 PM IST | New Delhi | IANSThe recent classification of talc as "probably carcinogenic to humans" by the World Health Organization's cancer agency, the International Agency for Research on Cancer (IARC), is a significant development in the ongoing debate about the safety of talcum powder, Dr Salil Patkar, consultant-medical oncology, Fortis Hiranandani Hospital, Vashi (Navi Mumbai), said on Sunday. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; According to the doctor, the use of talcum powder is widespread, and many people are unaware of the potential risks associated with it. "While the evidence is not yet conclusive, it is essential to err on the side of caution when it comes to public health," Patkar said. "The link between talcum powder and ovarian cancer is plausible, as talc particles can travel through the reproductive system and cause inflammation and damage to the ovaries. This inflammation can increase the risk of cancer," he added. The cancer agency classified talc as "probably carcinogenic to humans" on the basis of a combination of limited evidence for cancer in humans (for ovarian cancer), sufficient evidence for cancer in experimental animals, and strong mechanistic evidence that talc exhibits key characteristics of carcinogens in human primary cells and experimental systems. According to the agency, numerous studies showed an increase in the incidence of ovarian cancer in humans self-reporting the use of body powder in the perineal region. An increased rate of ovarian cancer was also observed in studies looking at occupational exposure of women exposed to talc in the pulp and paper industry, it added. Patkar mentioned that it is crucial for individuals, especially women, to be aware of the potential risks associated with talcum powder use. "Alternative products, such as cornstarch-based powders, can be used instead. Additionally, manufacturers should take responsibility for informing consumers about the potential risks and providing safer alternatives," he said. Based on the current evidence, the doctor suggested that it is essential to exercise caution and consider "the potential risks associated with talcum powder use". This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} };
08 July,2024 01:07 PM IST | New Delhi | IANSHealth experts have a piece of good news for diabetic patients: recent studies highlight that there exist certain superfoods, which can enhance insulin sensitivity, reduce inflammation and support metabolic health. Dr Debojyoti Dhar, who studies complex genomics at Leucine Rich Bio, Bengaluru, informs, “The key bioactive compounds present in these superfoods improve insulin action by signaling pathways, contributing to improved metabolism and potentially preventing the onset of type 2 diabetes.” Insulin resistance can go undetected for 10 to 15 years, informs Dr Biju KS, senior medical officer, Vieroots. Most people discover their insulin resistance quite late, only along with a diagnosis of type 2 diabetes, prediabetes or unresponsive obesity. But, why does insulin resistance occur in the first place? Dr Rajiv Kovil, the head of diabetology at Zandra Healthcare, Mumbai breaks it down for us: Our bodies produce insulin, a type of hormone produced by the pancreas which aids in utilising sugar from food to increase energy levels. Your liver tends to store this sugar for future use. When you eat or drink something, your blood sugar levels rise significantly. Later the insulin helps move sugar obtained from these foods into cells so they can use it effectively. Insulin resistance happens when your body’s cells cannot respond well to the insulin. Simply put, your body needs two times more insulin to get the same amount of sugar into your cells. Kovil stresses this could lead to serious health conditions like high blood sugar levels and diabetes. He shares signs of insulin resistance: A waistline over 40 inches in men and 35 inches in female2. Blood pressure above 130/80 or Higher.3. Fasting glucose level above 100 mg/dl4. Fasting Triglycerides are high above 150 mg/dl Combatting weakened insulin action among diabetic people, Midday consulted experts—including scientists, diabetologists, nutritionists, and a dietician—to suggest a guide on superfoods that enhance insulin sensitivity. Here is what they recommend: 12 superfoods to enhance insulin sensitivityRecent research shows that superfoods such as berries, nuts and leafy greens can mitigate insulin resistance due to their rich antioxidant and anti-inflammatory properties, informs Dhar. For example, blueberries contain bioactive compounds that enhance insulin sensitivity and glucose metabolism. Additionally, foods rich in omega-3 fatty acids, such as fatty fish, have been shown to reduce inflammation and improve insulin function. When it comes to devising a diet rich in superfoods, one must add to it other fibrous foods to ensure meals contain the right amount of complex carbohydrates and protein, informs Rutu Dhodapkar, clinical dietician at P D Hinduja Hospital & MRC, Khar. She suggests the following foods to incorporate for better insulin action: Dark green leafy vegetables – Packed with vitamins and minerals such as Vitamin A, Vitamin C, Vitamin K, folate, iron, calcium and potassium, these foods are also rich in complex carbohydrates and low in calories. Avocado – Loaded with nutrients, fat-soluble vitamins and fiber, avocados help keep the heart healthy. They are high in vitamin E, which can reduce oxidative stress and aid in glucose management when added to the diet. Beans, dried peas and legumes – These plant-based protein superstars are rich in fibre, folate, potassium, iron and zinc. Choose good plant protein like kidney, pinto beans, black beans, chickpeas, peas lentils. Fish – Fish oils rich in omega 3 fatty acid, Salmon, Mackerel, Trout Tuna. The preparation matters Boil, bake or Grilled is allowed. Eg – can have as it is in Roasted / Grilled form with sautéed vegetables or can include in salads Nuts – Rich in healthy fats magnesium and fiber. This helps in managing hunger. Walnut and Flax seeds are rich in omega-3 fatty acids. Berries – Packed in antioxidants, vitamin C, K, manganese, potassium and fibre, berries are naturally sweet and can be added as a sweetening source for dessert. Citrus fruits – Rich in Vitamin C, folate, fibre and potassium, it’s better to have fruit one at a time as a whole to get the required benefits. Whole grains – Including millets in the diet is beneficial as they are high in fibre, rich in Vitamin B and have a low glycaemic index. Additionally, millets are gluten-free, making them ideal for those who cannot tolerate wheat and those on a weight reduction diet. Pumpkin Seeds – High in magnesium, fibre and healthy fatty acids, these foods help manage blood sugar levels. They should be included in the diet of an insulin-resistant patient, as most insulin-resistant patients have low magnesium levels. Chia seeds – Rich in antioxidants, Omega 3 fatty acids, fibre and magnesium, these seeds help in reducing blood sugars. Ginger – Known to decrease inflammation in the body also high in antioxidants, ginger can be used in juice form, grated form added in soups as warm in nature can be added to tea. Cinnamon – This spice helps to reduce blood sugar levels and also lowers lipid levels. Coming to Ayurveda, Biju shares that there are certain herbs and spices like turmeric and moringa that are noted for their action against insulin resistance. Similarly, in yoga, meditation and pranayama (breathwork), there are specific methods to fight insulin resistance. Also read: Rujuta Diwekar shares 5 food tips to prevent monsoon illnesses Enhancing the potency of superfoodsThere are exist specific cooking and preparation methods which can enhance the insulin-regulating properties of these superfoods. Sanchi Tiwari, Nutritionist, Lord’s Mark Biotech, remarks, "How you cook these superfoods can make a big difference in enhancing their benefits for managing insulin resistance. Here are a few methods that are particularly effective:Baking: When you bake foods like nuts, seeds and even some veggies, it helps keep their nutrients intact. Plus, you avoid adding unhealthy fats that you might get from frying.Broiling: This is a great method for vegetables and lean proteins. Broiling at high temperatures can help retain nutrients and bring out the flavors, and it's quick, so more of the good stuff stays in the food.Stewing: If you're cooking beans, legumes, or leafy greens, stewing is fantastic. It allows them to cook slowly, which helps keep their nutrients. Plus, it can make some of the beneficial compounds easier for your body to absorb.Roasting: Roasting veggies like sweet potatoes, Brussels sprouts, and carrots enhances their natural flavors while preserving their antioxidants. Using healthy oils, like olive oil, can also add good fats to your dish. Alternate vegan, gluten free dietStudies demonstrate the benefits of plant-based diets in treating type 2 diabetes and reducing key diabetes-related macrovascular and microvascular complications. There are a variety of plant-based proteins you can eat to help meet your protein needs such as: Pulses like lentils, chickpeas, and beans Soy products such as tempeh and tofu. Do superfoods really work?While there is a big buzz about superfoods on social media, how effective are they? Dhar shares sheds light on a clinical trial his team conducted at Leucine Rich Bio. “We completed a clinical trial utilising, Bugspeaks, a gut microbiome test based on nutritional recommendations on diabetic patients. The results have been positive and recently it got accepted in a peer-reviewed international scientific journal.” Additionally, he shares that there have been clinical trials to indicate the effectiveness of superfoods in preventing insulin resistance and improving Type 2 diabetes conditions. For instance, trials have shown that consumption of anthocyanidin-rich fruits reduced the risk of Type 2 diabetes by 23 percent. Similarly, trials have shown that consumption of almonds, walnuts, etc. improved metabolic health biomarkers and also the gut microbiota. The role of lifestyleBiju remarks that while a sedentary life can contribute to the development of insulin resistance, it is a myth that exercise can directly reduce insulin resistance. Rather, regular exercising of moderate intensity and duration opens up an alternate pathway for cellular uptake of glucose, especially in skeletal muscles, which is independent of insulin, but which in the long-term is beneficial against insulin resistance, as it reduces the demand for insulin. Dhar adds that dietary and lifestyle factors play a vital role in maximising the effects of superfoods on insulin sensitivity. A well-balanced diet rich in nutrients can boost the advantages of superfoods such as berries, nuts and leafy greens, all of which have been shown to improve metabolism. Almost all of the superfoods mentioned have a positive effect on the gut microbiota as well which can also help in improving insulin resistance conditions and overall glucose homeostasis. Maintaining a low glycemic index diet and preserving macronutrient balance also improves these effects. Regular physical exercise, appropriate sleep and stress management are all helpful for improving insulin function. Individuals who incorporate superfoods into a holistic lifestyle approach can greatly improve their insulin sensitivity and overall well-being. The science behind superfoodsSuperfoods help in improving insulin sensitivity in many ways. To elucidate, Garima Dev Verman, certified nutritionist and medical content analyst at The Healthy Indian Project (THIP), shares that egg whites contain high-quality protein and can potentially help people with insulin resistance by slowing down the absorption of glucose from the digestive tract. Speaking of chia and fenugreek seeds, both seeds provide soluble fibre that slows down carbohydrate absorption, stabilises blood sugar and improves insulin resistance. Every ingredient that we eat has its mechanism to combat insulin resistance. Incorporating superfoods into a daily meal can support the effective management of insulin resistance alongside regular physical activity. Kovil puts it simply: insulin sensitivity means how effectively our body cells respond to insulin. Good sensitivity towards insulins implies the cells make use of insulin efficiently, which later helps in keeping your blood sugar levels in control. With superfoods heavy on fibre and phytonutrients, they fight away internal inflammation. This further leads to lower oxidative stress which helps prevent cells and insulin receptors from getting damaged, resulting in improved insulin sensitivity. Some research claims that fiber and nutrient content present superfoods like green leafy vegetables and whole grains can help manage blood sugar levels and also improve the efficiency of insulin. Including superfoods like berries, and nuts regularly in your meal can effectively reduce inflammation encouraging cells to respond well to insulins. They particularly contain omega-3 fatty acids and healthy fats which not only help improve the functioning of the cells but also prevent sudden insulin spikes. However, it is crucial to note that more research is still needed to effectively understand the mechanism behind how superfoods encourage insulin sensitivity. More detailed research can help determine the long-term effects and how exactly they interact with various factors like genetic makeup, lifestyle habits and food choices. Recipes to incorporate superfoods into your diet Nutrition expert Garima Dev Verman shares 3 recipes infusing superfoods: Chia seed and yoghurt smoothie Ingredients:Chia seeds, 1 tspGreek yoghurt (dahi), 2 tbspCinnamon, 2 small size sticksHoney (optional) Method:Blend chia seeds, Greek yoghurt and a pinch of cinnamon until smooth.Sweeten with honey if desired. Roasted chickpea snack Ingredient:Roasted chickpeas, 1 cupChaat masala, 1 tspBlack salt, as per tasteCayenne pepper (optional) Method:In a bowl, combine the chaat masala, black salt, and cayenne pepper (if using).Add the roasted chickpeas to the bowl and toss them thoroughly to ensure they are evenly coated with the spice mixture.Enjoy your spicy and tangy roasted chickpea snack immediately, or store it in an airtight container for later. Egg white curry (Anda Curry) Ingredients:Egg whites, 6Onions, 2Tomatoes, 2Ginger garlic paste, 1 tbspTurmeric powder, 1/2 tspCumin powder, 1 tspCoriander powder, 1 tspGaram masala, 1/2 tspSalt, to tasteOil, 2 tbspFresh coriander leaves for garnish (optional) Method:Boil the eggs, remove the yolks, and chop the egg whites into bite-sized pieces. Set aside.Heat the oil in a pan over medium heat.Add the finely chopped onions and sauté until they turn golden brown.Add the ginger-garlic paste to the onions and cook for 2-3 minutes until the raw smell disappears.Add the chopped tomatoes to the pan and cook until they become soft and start to release oil.Add turmeric powder, cumin powder, coriander powder, and salt to the tomato-onion mixture.Cook for another 3-4 minutes, allowing the spices to blend well.Add the chopped egg whites to the pan and gently mix them with the masala, ensuring the egg whites are well-coated with the spices.Sprinkle garam masala over the curry and mix well.Cook for another 2-3 minutes to allow the flavours to meld together.Garnish with fresh coriander and serve hot.Serve hot with rice, roti, or naan. Also read: Zika virus: Mumbai doctors reveal insights about the mosquito-borne virus
08 July,2024 12:37 PM IST | Mumbai | Ainie RizviMany developing countries in the Asia-Pacific region, including the Philippines, still have a high tuberculosis (TB) incidence rate, according to an article published in the Asian Development Blog of the Asian Development Bank (ADB). Citing World Health Organization (WHO) data, the recently published article said the highly infectious disease "remains rife" in the region, with Southeast Asia responsible for 46 per cent of global infections in 2022, "the highest in any region", Xinhua news agency reported. The article also said the pandemic devastated national TB prevention and treatment programmes, causing an estimated half a million excess deaths between 2020 and 2022. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; However, the good news is that there has been a post-pandemic recovery in the number of people diagnosed with and treated for TB, helping to reduce the damage done by the pandemic, it added. According to the WHO Global Tuberculosis Report 2023, the Philippines, along with Indonesia, Mongolia, Papua New Guinea, and Vietnam, have some of the highest levels of TB in the region -- around 700,000 people out of a population of 115 million have active TB. Nearly 10 million people in the Philippines reside in impoverished urban areas. Poverty and overcrowding, along with poorly-resourced public health services, are major factors in the widespread incidence of TB in the country, according to The Lancet. In Indonesia, TB is the fourth-highest cause of death overall, and among those aged 15 to 49 years, it is the number one cause of death by a contagious disease. TB, an airborne disease spawned by urban poverty, is currently the world's second-biggest infectious killer after Covid-19. Many countries are working to eliminate TB by 2030, which aligns with the WHO's End Tuberculosis Strategy. The article said adapting practices such as mask-wearing and improved hygiene at home and work that proved effective against Covid-19 could play an important role in helping Asia and the Pacific rid themselves of TB permanently. However, socioeconomic factors, including poverty, overcrowding, poor sanitation, lack of infrastructure, and inadequate public health systems, allow the disease to remain endemic, it added. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
07 July,2024 03:08 PM IST | Manila | IANSA 67-year-old man from Uzbekistan has been given a new lease of life after being successfully treated for his rare colonic tumour via robot-assisted surgery. "This marks the world's first robot-assisted surgery for the condition," according to a statement from Amrita Hospital, Faridabad. The patient was presented to doctors with a special condition where his liver and colon were positioned differently (situs inversus partial), and he had a malignant tumour in this mispositioned colon. Situs inversus partial is quite rare, with overall incidence (including both totalis and partial) being approximately one in 10,000 people. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; The tumour was found to be a rare variant of colonic malignancy. The tumour was obstructing the patient's large intestine, preventing him from eating solid foods and posing a risk of spread and complications. His symptoms included vomiting, inability to eat, weight loss, anaemia, and abdominal distension. "Robot-assisted surgery significantly enhances precision and accuracy during procedures through its advanced features. The operation was conducted using a console that provides a magnified, high-resolution 3D view of the surgical site, offering superior depth perception and detailed anatomical visuals," said Abhishek Agrawal, Robotic GI Oncosurgery Consultant, Department of Gastrointestinal Surgery, Amrita Hospital, Faridabad, who led the six-hours long surgery. By the third day, the patient was able to resume a normal diet and was discharged just a week after the procedure, the hospital said. "Based on the final biopsy report, the patient will need to undergo chemotherapy. After completing the treatment, he will only require routine blood tests and imaging for surveillance to detect any early recurrence and receive timely treatment. They can continue with their normal life without the need for long-term medications or restrictions," said Saleem Naik, Senior Consultant, GI Surgery, Amrita Hospital, Faridabad. "The robot-assisted surgery not only relieved my symptoms but also improved my quality of life significantly. I can now eat normally and live without the constant pain and discomfort that I was experiencing," said the patient, thanking the doctors. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever.
07 July,2024 03:07 PM IST | Faridabad | IANSIn a tragic incident, a tenth-standard student died due to heart failure at a school in Bandikui in Rajasthan's Dausa district on Saturday. The deceased identified as Yatendra (16) reached the school at 7.30 a.m. on Saturday but collapsed on the corridor just before entering the classroom. The school administration immediately rushed Yatendra to a nearby hospital where he died during treatment. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; Circle Inspector Premchand said, "Yatendra, the son of Bhupendra Upadhyay studying in a private school on Panditpura Road, suddenly fell unconscious on Saturday morning. The school staff took him to the Bandikui Government Hospital the doctors declared him dead after 10 minutes of treatment. According to the doctors, Yatendra died due to heart failure." As per reports, Yatendra had a hole in his heart since childhood for which he was undergoing treatment. "The deceased's family refused to conduct a post-mortem. Going by the doctor's statement and Yatendra's medical history, the police have not filed any case in the matter. The family has left for their ancestral village at Narwas in Alwar to perform the last rites." Bhupendra Upadhyay, the deceased's father, said: "Yatendra turned 16 only on Friday. He even distributed toffees among his schoolmates and cut a cake at home. He also got photographs taken with the family members. But yesterday's happiness has turned into sorrow today." Also read: Mumbai KEM patients’ reports reincarnated as ‘paper plates’, BMC orders probe This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
07 July,2024 03:06 PM IST | Mumbai | IANSCytomegalovirus (CMV) is a common and symptomless herpes virus that can cause serious harm to newborn babies and people with impaired immune systems like organ transplant and HIV patients, said experts here on Saturday. CMV belongs to the herpes virus family and can infect people of all ages. It spreads through body fluids and usually remains dormant, causing no symptoms or a mild illness characterised by fever, sore throat, fatigue or swollen glands. But it can prove to be risky for some people. CMV is the most commonly transmitted virus to a developing foetus. In people with weaker immune systems, CMV can produce serious symptoms affecting the eyes, lungs, oesophagus, intestines, stomach, or liver. “If a pregnant woman contracts CMV for the first time during pregnancy (primary infection), there is a risk of transmitting the virus to the unborn baby. This can result in congenital CMV infection, which may cause developmental problems, hearing loss, vision impairment, and other serious health issues in the baby,” Dr Neha Rastogi Panda, Consultant-Infectious Diseases, Fortis Memorial Research Institute, Gurugram, told IANS. “CMV is a common virus that infects over 90 per cent of the Indian population during pregnancy (intrauterine) or early childhood. While typically harmless in healthy individuals, CMV can become a serious threat to people with HIV/AIDS or those undergoing organ transplants (especially kidney and bone marrow). In these cases, the virus can reactivate and cause a range of health problems,” added Dr Rajeev Gupta, Director - Internal Medicine at the CK Birla Hospital (R), Delhi. CMV in people with low immunity on steroids, cancer, and dialysis can reactivate and cause symptoms like fever, pneumonia, gastrointestinal symptoms, and visual effects and problems. Dr Neha said that CMV is a significant cause of morbidity and mortality in people with weakened immune systems. While there is no widely available vaccine specifically to prevent the initial infection with CMV, antiviral medications administered during organ transplant procedures significantly reduce the risk of CMV reactivation. The doctors called for maintaining hygiene by washing hands regularly, practising safe sex, not sharing items like toothbrushes, and avoiding contact with bodily fluids. Also read: Discover 12 superfoods to fight insulin resistance
06 July,2024 09:58 PM IST | Mumbai | IANSThe BrihanMumbai Municipal Corporation (BMC) has ordered a probe into a bizarre revelation of the KEM Hospital patients’ old medical reports getting reincarnated as ‘paper plates’ in the market, officials said here on Saturday. The opposition Shiv Sena (UBT) and Maharashtra Navnirman Sena (MNS) highlighted the issue after some videos of the development went viral on social media. While MNS spokesperson Sandeep Deshpande shared the video, the SS (UBT) leaders like Anil Choudhary, Kishori Pednekar and Shraddha Jadhav rushed to the hospital to demand an explanation from the authorities of the civic-run premier medical institution. Besides the high-level probe by a Deputy Municipal Commissioner (Public Health), the BMC has also slapped a memo to one of its service providers and sought an explanation from the KEM authorities on the issue. The SS (UBT) leaders sought to know how the confidential medical reports of patients were ostensibly ‘sold’ away as waste and returned in a new avatar as ‘paper plates’, displaying the names, addresses, the medical department and other details of those who were treated at KEM Hospital. Rattled by the furore, the BMC said that after various tests like x-rays, MRIs or CT scans, the patients were given the report in a folder. These folders were either outdated or old and later destroyed into a shredder before being disposed of as scrap by the concerned service provider of the BMC. However, in this instance, it was found that the vendor had reportedly sold out the folders without shredding them, amounting to negligence, said the BMC. A civic source said that in the past couple of years, the civic hospitals have initiated a major project to digitise the medical reports of all its patients but said it was a mystery how the old folders emerged again as ‘paper plates’. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
06 July,2024 09:37 PM IST | Mumbai | IANSWant to maintain sharp memory skills and cognitive function as you age? Cutting down on smoking suggests a large study that found it to be a key lifestyle factor linked to cognitive decline. atOptions = { 'key' : 'd0ddb8ef8f1a62a8cdd22fac27fc5ea7', 'format' : 'iframe', 'height' : 90, 'width' : 728, 'params' : {} }; The study, published in Nature Communications, is based on a 10-year survey of 32,000 adults aged 50 or over from 14 countries in Europe. The team led by researchers from the University College London, UK showed that cognitive decline was faster for lifestyles that included smoking. People who smoked had cognitive scores that declined up to 85 per cent more over 10 years than those who did not. Lead author Mikaela Bloomberg (UCL Behavioural Science & Health) said the study "is observational; it cannot definitively establish cause and effect, but it suggests smoking might be a particularly important factor influencing the rate of cognitive ageing". As per previous studies, people who engaged in more healthy behaviours like regular exercise, and moderate alcohol intake have slower cognitive decline. However, it did not specify whether all behaviours contributed equally to cognitive decline. Also Read: Physical inactivity on the rise: Experts share ways to incorporate exercise amid sedentary lifestyle and hectic schedules However, the new study showed that among the healthy behaviours, "not smoking may be the most important in terms of maintaining cognitive function". Among those unable to stop smoking, the study suggests engaging in other healthy behaviours such as regular exercise, moderate alcohol consumption, and remaining socially active "to offset adverse cognitive effects", Mikaela said. This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever
06 July,2024 06:53 PM IST | New Delhi | IANSADVERTISEMENT
