Samantha Ruth Prabhu made a sparkling debut with 'Ye Maaya Chesave' in Telugu which was a hit. She was starred opposite Naga Chaitanya in this sweet love story. Samantha played Jessie in this complicated inter-religion love story. Her performance was praised by critics and audience alike and was said to be 'the one to watch out for'

In 2012, Samantha starred in SS Rajamouli's fantasy film 'Eega'. The film's narrative is in the form of a bedtime story told by a father to his daughter. Its protagonist Nani, who is in love with his neighbour Bindu, is murdered by a wealthy industrialist named Sudeep, who is attracted to Bindu and considers Nani a rival. Nani reincarnates as a housefly and tries to avenge his death and protect Bindu from an obsessive Sudeep.

Samantha played the role of Bindu and received the Best Actress award at Filmfare

Samantha plays Yamuna in the 2015 Tamil film 'Thanga Magan' opposite Dhanush. The two actors play a married couple who try to uncover the reason behind Dhanush's character Tamizh's father's suicide

Directed by Atlee, Samantha starred as Vijay's wife in Theri. She is seen in the flashback segment of the film where the events to her murder is unfolded and how she saves her daughter and makes her police officer husband vow to always protect their daughter

In the 2017 film 'Mersal', directed by Atlee, Samantha was reunited with her Theri co-star Vijay. She plays a doctor in the film and fiance of Vijay's character Maaran. Vijay is seen in a triple role in the film

In 2018, Samantha transformed herself completely into village girl Ramalakshmi in Sukumar's film 'Rangasthalam. “Everything about the film and my role is on a different tangent. Sukumar was very clear that he didn’t want to see Samantha at all. I had to walk, talk, and even laugh like Ramalakshmi. There was a scene where I laughed like I normally do, and Sukumar asked for a retake and asked me to make the laugh sound ugly," she had once said

Samantha got a chance to show her range as an actor with this Netflix film which has four interwoven stories shown in parallel. Samantha plays a quirky woman whose lover dies in between sex. She seeks her husband's help in getting rid of the body without raising suspicion. Fahadh Faasil plays her husband in the film. The film was released in 2019

Samantha Ruth Prabhu plays the understanding Sravani, wife to Naga Chaitanya's character Poorna. She puts up with Poorna's indifference to her and their marriage without any complaints, till she transforms him with her love for him. The film was released in 2019

Oh Baby! brought out a completely different side of Samantha who played the character of a woman who physically looked like someone in her 20s but was mentally in her 70s

A remake of the Tamil film '96, 'Jaanu' film revolves around the reunion of former students from a 2004 batch class fifteen years after their graduation. The reunion also serves as an opportunity for two former lovers, Ram and Janu, to resolve issues surrounding their breakup

Samantha Ruth Prabhu had everyone surprised with her performance as a member of LTTE in the show 'The Family Man 2'. From portraying trauma to doing action-packed scenes, the actress was lauded for her stunning performance and received many awards

Samantha stole the limelight with her performance in the song 'Oo Antava' with her hotness quotient and sizzling dance in the 2021 film 'Pushpa: The Rise'. The song also featured Allu Arjun but Samantha was the highlight of the dance number

In 2022, Samantha was seen headlining the film Yashoda. The film revolves around an innocent woman who agrees to be a surrogate mother at a highly plush facility to find her missing sister. However, she uncovers the shocking truth about the centre. While Samantha gave a great performance, the film failed to connect with the audience

In 2023, Samantha transformed into Shakuntala for the film 'Shaakuntalaam' where she personified grace

Samantha's latest film is Kushi where she plays a Muslim girl working as a corporate employee in Kashmir

The film directed by 'Majili' fame Shiva Narana also stars Vijay Deverakonda. This is Vijay and Samantha's second collaboration after Mahanati