Sanjana Sanghi was 14 when she made her acting debut in Imtiaz Ali's Rockstar. Sanjana played Nargis Fakhri's younger sister in the film.

"Rockstar will always remain much more than just a film, for everyone who created it and everyone who watched it. As a 14-year-old studying in school, I was not remotely aware of the magic being created around me. In hindsight, it changed something within me forever. I don't remember the grandeur, but I vividly remember some feelings, some moments, some smells - through the valleys of Kashmir, the quaintness of Dharamshala and the quirkiness of Delhi," Sanjana Sanghi wrote on social media.

In 2019, on November 11, she shared this picture and wrote in the caption, "8 years of the magic that’ll cease to ever exist again, 8 years of start of something so beautiful, 8 years of undying gratitude."

In 2017, Sanjana Sanghi appeared in Irrfan Khan-starrer Hindi Medium. She played the role of young Mita, whose adult version was played by actress Saba Qamar. When Irrfan Khan passed away, Sanjana shared a small video of her part in the film and wrote in the caption: That's a clipping from the theatres of the first day first show of Hindi Medium, on May 19, 3 years ago. I could never have imagined that 3 years later - May 19, 2020, would be a day we'd be in a world without Irrfan Sir, and with theatres shut globally. The oddity of our current times, sometimes really does frighten me. Regardless! Here's celebrating 3 years of this beautiful film. Forever grateful for being such a small part of such a beautiful story.

In 2018, Fox Star Studios announced that Sanjana has been roped in to play the lead actress in their film Kizie and Manny starring Sushant Singh Rajput, marking the directorial debut of casting director Mukesh Chabbra. The film's title was later changed to Dil Bechara.

The film saw a lot of delays in its release and shooting dates. However, what is more tragic is that the film will mark bonafide actor Sushant Singh Rajput's last film, as he passed away on June 14, 2020. After his demise, Sanjana Sanghi took to Instagram to share this candid picture of Sushant and hers on the sets of the film and wrote in the caption, "Oye? I need to laugh till my stomach hurts at all your bad jokes. I need to compete with you on who can eat more ham & cheese omelettes and drink more chai. Fight with you over who’s script looks more tattered and worn out because we worked on it endlessly. Try to keep up with your electric pace every time you said, "Chal na, thoda dance karte hain!" in the middle of a tough scene. And argue with you over what we feel about Yuval Noah Harrari & Freud’s books. UGH."

Dil Bechara is the story of Kizie Basu and Immanuel Rajkumar Junior or Manny and explores the funny, thrilling, and tragic adventure of being alive and in love. Together, Kizie and Manny embark on an on-off-up-down-sad and sweet profound journey into the heart of that crazy little thing called life. It teaches them what it means to feel truly alive and fall in love. Amid the pandemic, the film will not release in theatres but will stream on Disney+ Hotstar from July 24 onwards.